- Engine
- Front-mounted 4,962 cc (5.0-litre) 60° V12, single overhead camshaft per bank, three Weber twin-choke carburettors — Ferrari 'tipo 208'; a unique hybrid of Lampredi long-block bore spacing and Colombo short-block heads, used in no other Ferrari
- Power
- ~395 bhp / 400 PS @ 6,500 rpm — the nominal factory rating for the 4,962 cc V12 in 500 Superfast specification
- Transmission
- 4-speed manual with electric overdrive on top gear (Series I); all-synchromesh 5-speed manual (Series II)
- Layout
- Front engine, rear-wheel drive — Pininfarina-designed steel bodyshell over a tubular chassis, body-completed by Scaglietti at Modena
- Top speed
- ~280 km/h (~174 mph) — factory-quoted figure for the era
- Production
- 36 built 1964–1966 (firm total) — Series I / Series II split cited as 25/11 or 24/12, both reconciling to 36
- Designer / assembly
- Body designed by Pininfarina and completed by Scaglietti at Modena; final assembly at Ferrari, Maranello, Italy